July 03, 2025 | Cosmetics Design |
A new study from Thailand’s Burapha University highlights the anti-ageing potential of mangosteen pericarp extract (MPE), derived from the fruit’s discarded peel. Rich in α-mangostin, the extract demonstrated strong antioxidant and anti-senescence effects in human dermal fibroblasts exposed to UVA radiation. Lab tests showed MPE reduced senescent cells by 41%, decreased MMP-1 (a collagen-destroying enzyme) by 39%, and boosted pro-collagen by 52%, indicating its role in preserving skin structure and slowing photo-ageing.
MPE also significantly lowered reactive oxygen species (ROS) under oxidative stress and showed UVA-absorbing capabilities, offering multi-layered skin protection. Importantly, the extract was found non-toxic up to 50µg/mL and maintained cell health, making it suitable for topical use.
Researchers noted MPE’s lipophilic nature limits skin penetration, suggesting nano-emulsion or liposome delivery systems may enhance its effectiveness. As demand grows for sustainable and scientifically backed natural ingredients, MPE offers promise for use in cosmeceuticals and supports the upcycling of agricultural waste.
With Thailand being a major mangosteen producer, commercialising MPE could benefit both the cosmetic industry and local farmers. However, in vivo studies are needed to confirm its efficacy and optimize application methods for skincare products.
