June 04, 2025 | Cosmetics |
The study conducted by Kyung Hee University, Korea, investigated the anti-inflammatory potential of Nephelium lappaceum (rambutan) peel extract and its major compound, geraniin, through both in vitro experiments and clinical trials. Rambutan peel is often discarded as waste, but it contains bioactive compounds with notable immunomodulatory properties.
In vitro experiments were performed by inducing inflammation with UV, infrared radiation, sodium dodecyl sulfate (SDS), lipopolysaccharides (LPS), and retinoic acid, followed by treatment with rambutan peel extract and geraniin. The results showed significant reductions in inflammatory cytokines, demonstrating strong anti-inflammatory activity. Building on these findings, clinical trials were conducted to evaluate the protective effects of the extract on human skin exposed to irritants such as UV, IR, SDS, retinol, and mechanical tape stripping. Parameters including transepidermal water loss and erythema were measured to assess skin barrier integrity.
The clinical results confirmed that the extract reduced erythema and protected against skin barrier disruption, indicating its potential as a natural skin-soothing and anti-inflammatory agent. Overall, the study highlights the potential use of rambutan peel extract, particularly its geraniin content, as a sustainable ingredient for cosmetic applications targeting skin protection and inflammation reduction.
