April 19, 2025 | Microbial Pathogenesis |
The study conducted by Burapha University, Thailand, examined the potential of mangosteen (Garcinia mangostana) peel extract as a natural alternative to synthetic antimicrobials in livestock farming environments. High-density animal production systems are prone to airborne microbial contamination, which has led to extensive use of antimicrobial drugs and increasing concerns about resistance development and environmental contamination.
This study evaluated the antimicrobial efficacy of mangosteen peel extract against bacteria and fungi commonly detected in swine and poultry farms. The extract showed strong inhibitory and bactericidal activities against several microbial species, including Staphylococcus epidermidis, Bacillus cereus, Bacillus siamensis, and Eurotium indicum, with low minimum inhibitory and bactericidal concentrations. Scanning electron microscopy indicated that the antimicrobial action was associated with disruption of microbial cell walls and membranes. In addition, the extract exhibited notable antioxidant activity, as demonstrated by ABTS, DPPH, and FRAP assays, which was linked to its high phenolic content. The extract also inhibited bacterial protease activity and displayed rapid killing effects in time–kill experiments.
Overall, the findings suggest that mangosteen peel extract can effectively reduce airborne microbial contamination in animal farming facilities and may serve as a sustainable antimicrobial and antioxidant agent, while also contributing to the valorization of agricultural by-products.
