Search
2023-12-28
Antinociceptive effect of Nephelium lappaceum L. fruit peel and the participation of nitric oxide, opioid receptors, and ATP-sensitive potassium channels

October 31, 2023 | Frontiers in Pharmacology |

Conducted by the Federal University of Sergipe, Brazil, this study delves into the therapeutic potential of Nephelium lappaceum (rambutan) fruit peel extract (EENL). With a focus on traditional medicine, the research aimed to assess EENL's antinociceptive effects and associated mechanisms, along with evaluating its acute toxicity in zebrafish. Through chromatography coupled with mass spectrometry, the study identified bioactive compounds, including (epi)-catechin, procyanidin B, and ellagic acid derivatives in EENL. Crucially, the extract exhibited no toxicity in zebrafish embryos. In mice models, oral administration of EENL demonstrated significant antinociceptive effects by modulating pain-related behaviors. The involvement of opioid receptors, nitric oxide, and KATP channels in mediating EENL-induced antinociception was highlighted. This comprehensive evaluation provides valuable insights into the pharmacological properties of Nephelium lappaceum, paving the way for potential therapeutic applications.

Read more

Viewed Articles
Antinociceptive effect of <span style="font-style:italic;">Nephelium lappaceum</span> L. fruit peel and the participation of nitric oxide, opioid receptors, and ATP-sensitive potassium channels
October 31, 2023 | Frontiers in Pharmacology |Conducted by the Federal University of Sergipe, Brazil, this study delves into the therapeutic potential of Nephelium lappaceum (rambutan) fruit peel extr
Dec 28, 2023
Read More
Characterization and differentiation of three rambutan seed oils using metabolomics coupled with chemometric methodology
July 08, 2024 | Food Bioscience |Researchers from Hainan University, China, conducted a comprehensive metabolomic analysis of rambutan seed oil, a potential source of edible vegetable oil with limited
Valorization of red pitahaya (<span style="font-style:italic;"> Hylocereus </span>sp.) peel through a multi-product cascade biorefinery approach towards bioactive food packaging films
December 11, 2024 | Food Biophysics|This study, conducted by researchers from Costa Rica (Universidad de Costa Rica) and Spain (Universidad de Córdoba), explores the efficient valorization of red pita
2025.01.23
Incorporation of fruits or fruit pulp into yoghurts: recent developments, challenges, and opportunities
May 2, 2025 | Frontiers in Food Science and Technology | Researchers from the Swedish University of Agricultural Sciences (Sweden), University of Alberta (Canada), Obihiro University of Agriculture an
2025.06.30
Red dragon fruit (<span style="font-style:italic;">Hylocereus polyrhizus</span>), a superfruit rich in betacyanins pigments with antioxidative potential for hepatoprotection: A review
February 8, 2025 | Future Foods |Researchers from UCSI University and Universiti Putra Malaysia (UPM), Malaysia, conducted a comprehensive review focusing specifically on red dragon fruit (Hylocereus
2025.06.30
Effective transformation of rambutan residues into value-added chemicals and materials for multiple applications
December 10, 2024 | Environmental Technology & Innovation |Researchers from Nguyen Tat Thanh University and Nong Lam University Ho Chi Minh City, Vietnam, conducted a review on the potential applicati
2025.03.27
TOP