October 31, 2023 | Frontiers in Pharmacology |
Conducted by the Federal University of Sergipe, Brazil, this study delves into the therapeutic potential of Nephelium lappaceum (rambutan) fruit peel extract (EENL). With a focus on traditional medicine, the research aimed to assess EENL's antinociceptive effects and associated mechanisms, along with evaluating its acute toxicity in zebrafish. Through chromatography coupled with mass spectrometry, the study identified bioactive compounds, including (epi)-catechin, procyanidin B, and ellagic acid derivatives in EENL. Crucially, the extract exhibited no toxicity in zebrafish embryos. In mice models, oral administration of EENL demonstrated significant antinociceptive effects by modulating pain-related behaviors. The involvement of opioid receptors, nitric oxide, and KATP channels in mediating EENL-induced antinociception was highlighted. This comprehensive evaluation provides valuable insights into the pharmacological properties of Nephelium lappaceum, paving the way for potential therapeutic applications.