Search
2024-07-23
Antifungal activity of Durio zibethinus Murray peel extract against Candida albicans: A preliminary study

March 02, 2024| Narra J |

Research carried out by Universitas Sumatera Utara, Indonesia, and Babcock University, Nigeria, tackles the increasing challenge of antifungal resistance in Candida albicans infections by investigating the antifungal properties of durian fruit peels (Durio zibethinus Murray). This research aimed to determine the antifungal activity of D. zibethinus peel extract against C. albicans by analyzing its minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC).

The study, conducted from July to October 2020, involved collecting durian peels from Simalungun Regency, Medan, Indonesia, and extracting them using a maceration technique with 70% ethanol to obtain D. zibethinus peel ethanol extract (DPEE). C. albicans samples were obtained from the Laboratory of Microbiology, Faculty of Medicine, Universitas Sumatera Utara. The antifungal activity was assessed using the diffusion method with six groups exposed to different concentrations of DPEE (6.25%, 12.5%, 25%, and 50%), along with ketoconazole (positive control) and dimethyl sulfoxide (negative control). The inhibition zones were analyzed using one-way ANOVA and Tukey post-hoc test.

The results showed that the 6.25% DPEE concentration produced the largest inhibition zone (17.26±5.64 mm) and significant differences were observed among the DPEE concentrations (p<0.05). The study also found that the MIC of DPEE was 0.78% and the MBC was 3.125% against C. albicans. These findings suggest that D. zibethinus ethanol extract has potential antifungal activity against C. albicans, warranting further investigation for more precise antifungal applications.

Read more

Viewed Articles
Antifungal activity of <span style="font-style:italic;">Durio zibethinus</span> Murray peel extract against <span style="font-style:italic;">Candida albicans</span>: A preliminary study
March 02, 2024| Narra J |Research carried out by Universitas Sumatera Utara, Indonesia, and Babcock University, Nigeria, tackles the increasing challenge of antifungal resistance in Candida albicans i
Jul 23, 2024
Read More
Characterization and differentiation of three rambutan seed oils using metabolomics coupled with chemometric methodology
July 08, 2024 | Food Bioscience |Researchers from Hainan University, China, conducted a comprehensive metabolomic analysis of rambutan seed oil, a potential source of edible vegetable oil with limited
Novel packaging chitosan film decorated with green-synthesized nanosilver derived from dragon fruit stem
August 16, 2024 | Food Hydrocolloids |The innovative use of dragon fruit stem extract (DSE), an agricultural byproduct, in synthesizing silver nanoparticles (AgNPs) and incorporating them into chitosa
2024.12.31
Mangosteen pericarp processing technology to create economic value and reduce biowaste
July 20, 2024 | Foods |Researchers from King Mongkut’s Institute of Technology Ladkrabang, Thailand, conducted a study comparing various mangosteen pericarp processing methods to evaluate their impact
2024.12.31
Pitaya (<span style="font-style:italic;">Hylocereus polyrhizus</span>) peel powder: a source of pigments, phenolic and antioxidants activity for use in food hydrocolloids
May 2, 2025 | Food Bioscience |Researchers from the Federal University of Pelotas and the Federal Institute of Education, Science and Technology Sertão Pernambucano, Brazil, conducted a study to evalu
2025.05.27
Red dragon fruit (<span style="font-style:italic;">Hylocereus polyrhizus</span>), a superfruit rich in betacyanins pigments with antioxidative potential for hepatoprotection: A review
February 08, 2025 | Future Foods |Researchers from UCSI University and Universiti Putra Malaysia (UPM), Malaysia, conducted a review focusing on red dragon fruit (RDF), Hylocereus polyrhizus, an impor
2025.03.27
TOP